The panel moderator will describe the context for the Future of Systems Engineering (FuSE) initiative to realize the Systems Engineering Vision 2035 followed by the panelists presenting their position statements identifying challenges, opportunities, development needs, and opportunities for collaboration. The exponentially increasing aspects of scale, interactions, complexity, uncertainties, and emerging technologies challenges our engineering of systems and systems of systems. Together with stakeholders in the systems engineering ecosystem, we must foster collaboration to innovate and build quality professional practice of system engineering, which continues to evolve in response to technical opportunities and political, economic, social, technological, environmental, and legal (PESTEL) challenges. Anticipating what systems engineering will and should be in the future has significant implications for research, education, training, certification, and resources. The panel is 90 minutes with the intent to allocate 50 percent of the time for participants to then engage with the panel and each other.